Cluster headaches are nothing short of monstrous. They affect approximately 5% of the population, more men than women. Cluster headache research doesn't seem very plentiful, perhaps because of the relatively low prevalence. That's small comfort to the sufferers of cluster headaches.
Dr. R. Andrew Sewell and Dr. John H. Halpern, Harvard researchers, are studying the effects of two substances -- psilocybin (found in certain mushrooms) and lysergic acid diethylamide (LSD) -- on cluster headaches. Feature Article.